SHC-transforming protein 1 (IPR029586)

Short name: Shc1/ShcA

Overlapping homologous superfamilies


Family relationships



The SH2-containing Shc adapter proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to the Ras/mitogen-activated protein kinase (MAPK) pathway [PMID: 11607835]. Three Shc genes were originally identified in mammals that encode proteins characterised by an amino-terminal phosphotyrosine binding (PTB) domain and a carboxy-terminal Src homology 2 domain. Shc1 (ShcA) is ubiquitously expressed, whereas expression of Shc2 (ShcB) and Shc3 (ShcC) appears to be limited to neuronal cells [PMID: 8760305].

Shc1 (ShcA) adaptor transduces phosphotyrosine-dependent signals downstream of receptor tyrosine kinases (RTK) and non-RTKs, which regulates signalling pathways in breast cancer cells [PMID: 1623525]. Its SH2 domain is critical for tumour survival during mammary tumorigenesis [PMID: 22286768], while its PTB domain functions as a biological sensor of phosphotyrosine signalling during breast cancer progression [PMID: 23695548]. Shc1 is required for transforming growth factor beta (TGF-beta)-induced breast cancer cell migration, invasion, and metastasis [PMID: 23277357]. It is also involved in signalling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis [PMID: 14665640].

GO terms

Biological Process

GO:0001525 angiogenesis
GO:0007165 signal transduction

Molecular Function

GO:0030971 receptor tyrosine kinase binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.