Prostaglandin G/H synthase 1 (IPR029580)

Short name: COX-1

Overlapping homologous superfamilies

Family relationships


Prostaglandin G/H synthase 1 (COX-1) and synthase 2 (COX-2) convert arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis [PMID: 16373578]. PGH2 is then metabolised to one of at least five bioactive prostaglandins, including PGE2, PGI2, PGF2alpha, PGD2, or thromboxane A2 (TxA2). These prostanoids have pleiotropic cardiovascular effects altering platelet and renal function, and acting either as vasodilators or vasoconstrictors [PMID: 12093889]. COX-1 and COX-2 are the two cyclooxygenase isozymes targeted by the nonsteroidal anti-inflammatory drugs (NSAIDs) [PMID: 14630509, PMID: 24819536].

COX-1 (cyclooxygenase-1) is highly expressed in stomach and platelets, where it catalyses the arachidonic acid (AA) conversion into prostaglandins, which protect the gastrointestinal tract and modulate platelet function [PMID: 24531199]. COX-1 may contribute to ovarian cancer development through stimulation of neovascularisation [PMID: 12615701]. It is also involved in neurodegenerative diseases, such as Alzheimer's [PMID: 22001217, PMID: 23083210].

GO terms

Biological Process

GO:0019371 cyclooxygenase pathway
GO:0006954 inflammatory response
GO:0001516 prostaglandin biosynthetic process
GO:0008217 regulation of blood pressure

Molecular Function

GO:0004666 prostaglandin-endoperoxide synthase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.