Transient receptor potential cation channel subfamily M member 5 (IPR029577)

Short name: TRPM5

Overlapping homologous superfamilies


Family relationships



The TRPM subfamily of mammalian TRP channels includes TRPM5, which is essential for the detection of bitter, sweet, and amino acid tastes [PMID: 15731110]. TRPM5 forms a nonselective cation channel that is activated by intracellular Ca(2+) [PMID: 15731110, PMID: 14657398]. In addition to the taste system, TRPM5 is expressed in chemosensory cells in the digestive tract, respiratory and olfactory systems. It is also found in pancreatic islets, where it contributes to insulin secretion [PMID: 24756718].

GO terms

Biological Process

GO:0006812 cation transport
GO:0034220 ion transmembrane transport
GO:0050909 sensory perception of taste

Molecular Function

GO:0005227 calcium activated cation channel activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.