Calcium homeostasis modulator protein 1 (IPR029568)

Short name: CALHM1

Overlapping homologous superfamilies


Family relationships


Calcium homeostasis modulator protein 1 (CALHM1) is a Ca(2+) channel controlling neuronal excitability [PMID: 23345406, PMID: 23884934]. In humans, it controls the Ca2+ dependent MEK, ERK, RSK and MSK signalling cascade in neurons [PMID: 23345406]. It may be involved in the pathogenesis of Alzheimer's disease (AD) [PMID: 24069280].

GO terms

Biological Process

GO:0006812 cation transport

Molecular Function

GO:0005227 calcium activated cation channel activity
GO:0005244 voltage-gated ion channel activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.