Retinoic acid receptor responder protein 2 (IPR029562)

Short name: Chemerin

Overlapping homologous superfamilies


Family relationships



Retinoic acid receptor responder protein 2 (also known as chemerin or TIG2) is an immunomodulating protein secreted predominantly by adipose tissue and skin. It is secreted in an inactive form and further processed to an active form through cleavage of its carboxyl terminus [PMID: 16096270]. It regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1) [PMID: 24446308]. It also binds to G protein-coupled receptor 1 (GPR1) and C-C chemokine receptor-like 2 (CCRL2) [PMID: 24446308]. Chemerin has been linked to obesity and inflammation. It also possesses antimicrobiological functions and may serve as a tumorsuppressor in skin [PMID: 24446308].

GO terms

Biological Process

GO:0006954 inflammatory response
GO:0050994 regulation of lipid catabolic process

Molecular Function

GO:0005102 signaling receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.