Family

(E2-independent) E3 ubiquitin-conjugating enzyme FATS (IPR029561)

Short name: FATS

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

FATS (fragile-site associated tumor suppressor, encoded by C10orf90) contains the ALMS motif and is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage [PMID: 20844083, PMID: 24240685]. It is a tumor suppressor involved in radiation-induced tumorigenesis and could be used as a biomarker in breast cancer to identify individuals likely to benefit from radiotherapy [PMID: 28402275].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER