Serine incorporator 5 (IPR029555)
Short name: Serinc5
Overlapping homologous superfamilies
- Serine incorporator/TMS membrane protein (IPR005016)
- Serine incorporator 5 (IPR029555)
Serine incorporator (Serinc) 1-5 constitute a family of carrier proteins that incorporate serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Serinc family members contain 11 transmembrane domains [PMID: 16120614]. In the rat brain, expression of Serinc1 and Serinc2 mRNA is up-regulated by induced seizures, whereas Seric5 is down-regulated, indicating a novel mechanism linking neural activity and lipid biosynthesis.
This entry represents Serinc5 (also known as Tpo1). It may play a role in myelin formation [PMID: 16405874].
- PTHR10383:SF16 (PTHR10383:SF16)