Serine incorporator 5 (IPR029555)

Short name: Serinc5

Overlapping homologous superfamilies


Family relationships


Serine incorporator (Serinc) 1-5 constitute a family of carrier proteins that incorporate serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Serinc family members contain 11 transmembrane domains [PMID: 16120614]. In the rat brain, expression of Serinc1 and Serinc2 mRNA is up-regulated by induced seizures, whereas Seric5 is down-regulated, indicating a novel mechanism linking neural activity and lipid biosynthesis.

This entry represents Serinc5 (also known as Tpo1). It may play a role in myelin formation [PMID: 16405874].

GO terms

Biological Process

GO:0042552 myelination
GO:0006658 phosphatidylserine metabolic process
GO:0006665 sphingolipid metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.