Serine incorporator 2 (IPR029554)

Short name: SERINC2

Family relationships


Serine incorporator (Serinc) 1-5 constitute a family of carrier proteins that incorporate serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids. Serinc family members contain 11 transmembrane domains [PMID: 16120614]. In the rat brain, expression of Serinc1 and Serinc2 mRNA is up-regulated by induced seizures, whereas Seric5 is down-regulated, indicating a novel mechanism linking neural activity and lipid biosynthesis.

This entry represents Serinc2.

GO terms

Biological Process

GO:0015825 L-serine transport
GO:0006658 phosphatidylserine metabolic process
GO:0006665 sphingolipid metabolic process

Molecular Function

GO:0015194 L-serine transmembrane transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.