Epithelial discoidin domain-containing receptor 1 (IPR029553)

Short name: DDR1

Overlapping homologous superfamilies


Family relationships



The discoidin domain-containing receptor (DDR) family includes DDR1 and DDR2. DDR family members are receptor tyrosine kinases (RTKs) whose activating ligands are various collagens [PMID: 9659900]. The proteins contain an extracellular discoidin domain, which binds various collagen proteins, and an intracellular tyrosine kinase domain.

Epithelial discoidin domain-containing receptor 1 (also known as DDR1) is involved in smooth muscle cell migration and matrix metalloproteinase expression [PMID: 12065315]. It is responsible for maintaining the normal structure of skin and kidney epithelia [PMID: 20884741]. The receptor may play a critical role in inducing tumour cell adhesion and invasion [PMID: 16234985]. Its structure has been solved [PMID: 24768818].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0038062 protein tyrosine kinase collagen receptor activity

Cellular Component

GO:0005887 integral component of plasma membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.