Astrocytic phosphoprotein PEA-15 (IPR029546)

Short name: PEA15

Overlapping homologous superfamilies

Family relationships



Astrocytic phosphoprotein PEA-15 is a multifunctional protein that is involved in different biological processes and regulates several signalling pathways [PMID: 19531639]. It contains N-terminal death effector domain (DED) and a C-terminal tail with irregular structure [PMID: 19531639]. Expression of PEA-15 oscillates throughout the cell cycle, and the loss of PEA15 accelerates cell cycle progression [PMID: 24710276].

PEA-15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade [PMID: 24710276]. It inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis [PMID: 10442631]. It also functions as a tumour suppressor by triggering the DNA damage-induced G2/M checkpoint and inhibiting RAS-mediated transformation [PMID: 24710276]. It is overexpressed in patients with type 2 diabetes [PMID: 21780113].

GO terms

Biological Process

GO:0000077 DNA damage checkpoint
GO:0042981 regulation of apoptotic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.