Calpain-8 (IPR029543)

Short name: CAPN8

Overlapping homologous superfamilies


Family relationships


Calpain-8 (CAPN8) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [PMID: 12843408, PMID: 24085852]. Calpain-8 and Calpain-9 are predominantly expressed in the gastrointestinal tract and are restricted to the gastric surface mucus (pit) cells in the stomach. They are involved in gastric mucosal defence [PMID: 17646163, PMID: 20686710].

GO terms

Biological Process

GO:0007586 digestion

Molecular Function

GO:0005509 calcium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.