Calpain-2 (IPR029539)

Short name: CAPN2

Overlapping homologous superfamilies


Family relationships


Calpain-2 (CAPN2, also known as m-calpain) belongs to the calpain family, which consists of a group of Ca2+ dependent cysteine proteases that regulate functions of substrates by proteolysis [PMID: 12843408, PMID: 24085852]. The most abundant members of the calpain familiy are CAPN1 and CAPN2. They form heterodimers, which are regulated by a small regulatory subunit (28 kDa) encoded by the gene Capn4 [PMID: 18515801]. CAPN2 is required for proteolysis of cytoskeletal and focal adhesion proteins, such as FAK, paxillin, spectrin, and talin [PMID: 15302585]. The cleavage of the cytoskeletal protein talin-1 (TLN1) by CAPN2 is critical for the disassembly of focal adhesions [PMID: 24085852].

GO terms

Biological Process

GO:0006508 proteolysis
GO:0051493 regulation of cytoskeleton organization

Molecular Function

GO:0005509 calcium ion binding
GO:0004198 calcium-dependent cysteine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.