Serine/arginine-rich splicing factor 1 (IPR029538)

Short name: SRSF1

Overlapping homologous superfamilies

Family relationships



Serine/arginine-rich (SR) proteins constitute a conserved family of RNA-binding proteins with roles in both constitutive and alternative splicing [PMID: 19061484]. Typically, SR proteins contain an N-terminal RNA-binding domain and a C-terminal RS domain that acts to promote protein-protein interactions [PMID: 8139654].

This entry represents the prototype member of the SR family, serine/arginine-rich splicing factor 1 (SRSF1 or SF2/ASF). SF2/ASF regulates constitutive and alternative splicing [PMID: 12626338]. It has also been shown to regulate diverse aspects of gene regulation, including mRNA stability [PMID: 11877379], translation [PMID: 18439897], and transcription [PMID: 18641664]. SF2/ASF is upregulated in several human tumours, including lung, colon, kidney, liver, pancreas and breast tumours [PMID: 17310252].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.