Transcription factor IIIB subunit Brf1 (IPR029529)

Short name: Brf1

Overlapping homologous superfamilies


Family relationships


Transcription by RNA polymerase III (pol III) is a complex molecular process orchestrated by the two main transcription factors, TFIIIB and TFIIIC. The TFIIIB complex can be recruited by TFIIIC to upstream DNA and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling [PMID: 11433012]. Saccharomyces cerevisiae TFIIIB is a complex of three subunits, the TATA box-binding protein TBP, the TFIIB-related factor BRF, and the beta'' protein.

This entry represents transcription factor IIIB subunit Brf1, which is a homologue of the functionally analogous pol II initiation factor, TFIIB [PMID: 11433012]. In budding yeast, Brf1 interacts with several initiation-specific subunits of the pol III machinery, TBP, beta", TFC4p and the pol III subunits C34 and C17 [PMID: 11433012].

GO terms

Biological Process

GO:0006383 transcription by RNA polymerase III

Molecular Function

GO:0001026 TFIIIB-type transcription factor activity

Cellular Component

GO:0000126 transcription factor TFIIIB complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.