Transcription factor GATA-1 (IPR029524)
Short name: GATA-1
Overlapping homologous superfamilies
- Transcription factor GATA (IPR039355)
- Transcription factor GATA-1 (IPR029524)
GATA-1 (also known as GATA-binding factor 1 or erythroid transcription factor) belongs to the GATA transcription factor family, which consists of a group of vertebrate GATA factors that have two highly conserved zinc finger motifs and recognise a six-nucleotide motif T/AGATAG/A in target genes. GATA-1 regulates the expression of multiple erythroid genes and is indispensable for erythropoiesis [PMID: 12032775]. It is also involved in the generation and function of megakaryocytic, eosinophilic, mast cell and basophil lineages [PMID: 24407241, PMID: 19279013, PMID: 20304827, PMID: 24167252]. GATA-1 forms distinct complexes with hematopoietic transcription factors and chromatin remodeling and modification complexes, acting both as activator and repressor of different target genes [PMID: 15920471, PMID: 16095949].
Mutations in GATA-1 gene cause a few blood diseases, such as X-linked dyserythropoietic anemia and thrombocytopenia (XDAT) [PMID: 10700180, PMID: 11809723], Thrombocytopenia with beta-thalassemia, X-linked (XLTT) [PMID: 12200364] and Anemia without thrombocytopenia, X-linked (XLAWT) [PMID: 16783379].
GO:0003700 DNA-binding transcription factor activity
- PTHR10071:SF190 (PTHR10071:SF190)