Transcription factor GATA-2 (IPR029522)

Short name: GATA-2

Overlapping homologous superfamilies


Family relationships


Transcriptional activator GATA-2 belongs to the GATA transcription factor family, which consists of a group of vertebrate GATA factors that have two highly conserved zinc finger motifs and recognise a six-nucleotide motif T/AGATAG/A in target genes. GATA-2 plays a central role in hematopoiesis, as well as vascular, lymphatic, and neural development [PMID: 22192845, PMID: 20670937]. Mutations in the GATA-2 gene cause a few blood diseases, such as Dendritic cell monocyte lymphocyte B and natural killer lymphocyte deficiency (DCML) [PMID: 21670465], Lymphedema, primary, with myelodysplasia (LMPM) [PMID: 21892158] and Myelodysplastic syndrome (MDS) [PMID: 21892162].

GO terms

Biological Process

GO:0030097 hemopoiesis

Molecular Function

GO:0003700 DNA binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.