Transcription factor GATA-3 (IPR029521)

Short name: GATA-3

Overlapping homologous superfamilies


Family relationships


GATA-3 belongs to the GATA transcription factor family, which consists of a group of vertebrate GATA factors that have two highly conserved zinc finger motifs and recognise a six-nucleotide motif T/AGATAG/A in target genes. GATA-3 is a trans-acting T-cell-specific transcription factor required for several developmental steps in T-cells [PMID: 20969588]. It may act as a regulator of the balance between self-renewal and differentiation in hematopoietic stem cells [PMID: 23974957].

GO terms

Biological Process

GO:0045582 positive regulation of T cell differentiation

Molecular Function

GO:0000976 transcription regulatory region sequence-specific DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.