Lysine-specific demethylase 6B (IPR029518)

Short name: KDM6B

Overlapping homologous superfamilies


Family relationships



This entry represents lysine-specific demethylase 6B (also known as JMJD3 or KDM6B). UTX (also known as KDM6A), JMJD3 (also known as KDM6B) and UTY (also known as KDM6C) are the members of the JmjC (Jumonji C) subfamily of the histone lysine demethylases family (KDM). They are histone demethylases that catalyse demethylation of H3K27, a mark important for transcriptional repression [PMID: 24798337].

Unlike KDM6A, KDM6B is highly regulated at the transcriptional level and is upregulated in response to oncogenic stress [PMID: 24797517, PMID: 19451217]. It is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner [PMID: 24797517]. It also plays important roles in osteoblast differentiation and regulates the expressions of bone sialoprotein and osteocalcin via transcription factors Runx2 and osterix [PMID: 24106268]. Its subcellular localisation is dynamically regulated and has pivotal roles for H3K27me3 status [PMID: 24646476].

GO terms

Biological Process

GO:0071557 histone H3-K27 demethylation

Molecular Function

GO:0071558 histone demethylase activity (H3-K27 specific)
GO:0046872 metal ion binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.