LAR-interacting protein, Liprin (IPR029515)

Short name: Liprin

Family relationships


This entry represents liprin family from vertebrates and invertebrates.

Liprin was originally identified as binding partners of the receptor protein tyrosine phosphatase LAR (leukocyte common antigen-related), which functions in axon guidance and mammary gland development [PMID: 9624153]. In vertebrates, there are two families of liprins, liprin-alpha and liprin-beta, which have four (alpha1-4) and two (beta1-2) members. In C. elegans and Drosophila, there are only one liprin-alpha (known as Syd-2 and Dliprin-alpha) and one liprin-beta. Another liprin family member, liprin-gamma, has also been identified in Drosophila [PMID: 21084592]. Liprins contain an N-terminal coiled-coil domain and a C-terminal liprin homology (LH) region comprised of three sterile alpha motif (SAM) domains [PMID: 21855798]. The N-terminal coiled coils of liprin-alpha mediate interactions with adapter proteins at the presynaptic active zone, while the SAM repeats bind proteins such as LAR receptor tyrosine phosphatase [PMID: 22072677].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.