LAR-interacting protein, Liprin (IPR029515)

Short name: Liprin

Overlapping homologous superfamilies


Family relationships


This entry represents liprin family from vertebrates and invertebrates.

Liprin was originally identified as binding partners of the receptor protein tyrosine phosphatase LAR (leukocyte common antigen-related), which functions in axon guidance and mammary gland development [PMID: 9624153]. In vertebrates, there are two families of liprins, liprin-alpha and liprin-beta, which have four (alpha1-4) and two (beta1-2) members. In C. elegans and Drosophila, there are only one liprin-alpha (known as Syd-2 and Dliprin-alpha) and one liprin-beta. Another liprin family member, liprin-gamma, has also been identified in Drosophila [PMID: 21084592]. Liprins contain an N-terminal coiled-coil domain and a C-terminal liprin homology (LH) region comprised of three sterile alpha motif (SAM) domains [PMID: 21855798]. The N-terminal coiled coils of liprin-alpha mediate interactions with adapter proteins at the presynaptic active zone, while the SAM repeats bind proteins such as LAR receptor tyrosine phosphatase [PMID: 22072677].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.