Domain

NACHT-associated domain (IPR029495)

Short name: NACHT-assoc

Domain relationships

None.

Description

This domain is frequently found associated with the NACHT domain (IPR007111) in fish and other vertebrates [PMID: 18039395]. Proteins containing this domain include NACHT, LRR and PYD domains-containing protein 3/12 (NLRP3/12). In humans, NLRP3 (also known as PYPAF1) may function as an inducer of apoptosis [PMID: 11786556]. NLRP12 is a non-inflammasome NLR (nucleotide-binding domain and leucine-rich repeat-containing receptors) that has been implicated in the regulation of Toll-like receptor-dependent nuclear factor-kappaB activation [PMID: 21978668].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam