Type I restriction enzyme R protein, N-terminal domain (IPR029464)

Short name: HSDR_N

Overlapping homologous superfamilies


Domain relationships



This entry represents the N-terminal domain found in type I restriction enzyme R (HSDR) proteins. Restriction and modification (R/M) systems are found in a wide variety of prokaryotes and are thought to protect the host bacterium from the uptake of foreign DNA [PMID: 11555298]. Type I restriction and modification systems are encoded by three genes: hsdR, hsdM, and hsdS. The three polypeptides, HsdR, HsdM, and HsdS, often assemble to give an enzyme (R2M2S1) that modifies hemimethylated DNA and restricts unmethylated DNA [PMID: 10449767].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.