Domain

Rapamycin-insensitive companion of mTOR, domain 4 (IPR029453)

Short name: Rictor_IV

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the domain 4 of the Rictor (rapamycin-insensitive companion of mTOR) protein. It is found in the more conserved central section that may include several individual domains

The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 [PMID: 15268862]. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling [PMID: 19995915]. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [PMID: 18089801].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam