Domain

Rapamycin-insensitive companion of mTOR, domain 5 (IPR029452)

Short name: RICTOR_V

Domain relationships

None.

Description

This entry represent the conserved domain 5 of the Rictor (Rapamycin-insensitive companion of mTOR) protein.

The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 [PMID: 15268862]. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling [PMID: 19995915]. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [PMID: 18089801].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam