Domain

Rapamycin-insensitive companion of mTOR, middle domain (IPR029451)

Short name: RICTOR_M

Domain relationships

None.

Description

This domain is found in the more conserved central section of Rictor (rapamycin-insensitive companion of mTOR) that may include several individual domains.

The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor is a component of mTORC2 [PMID: 15268862]. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling [PMID: 19995915]. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [PMID: 18089801].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam