Domain

GyrI-like small molecule binding domain (IPR029442)

Short name: GyrI-like

Domain relationships

Description

This entry represents a small molecule binding domain in a number of different bacterial transcription activators [PMID: 10802742] and DNA gyrase inhibitors (GyrI). In members of the GyrI superfamily this domain originated from a dimeric version of an SHS2 module that has been adapted for small-molecule binding [PMID: 15281131]. Members of the GyrI superfamily with this domain include a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira [PMID: 15281131].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam