Domain

Dynein regulatory complex protein 1, C-terminal (IPR029440)

Short name: DRC1_C

Domain relationships

None.

Description

This entry represents the C-terminal domain of dynein regulatory complex protein 1 (DRC1, also known as CCDC164). DRC1 is a key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. It is required for the assembly and regulation of specific classes of inner dynein arm motors. It may also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending [PMID: 23354437].

Mutations of DRC1 gene cause Ciliary dyskinesia, primary, 21 (CILD21), which is a disorder characterised by abnormalities of motile cilia [PMID: 23354437].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam