Family

Tumour protein p53-inducible nuclear protein (IPR029431)

Short name: TP53INP

Family relationships

Description

This entry represents tumour protein p53-inducible nuclear protein 1 and 2 (Tp53inp1 and Tp53inp2). There is only DOR/Tp53inp2 in invertebrates, while both Tp53inp1 and Tp53inp2 can be found in vertebrates. The vertebrates Tp53inp1 gene may have arisen by gene duplication [PMID: 22470510].

Tumour protein p53-inducible nuclear protein 1 is an antiproliferative and proapoptotic protein involved in cell stress response. It acts as a dual regulator of transcription and autophagy [PMID: 11511362].

DOR/TP53INP2 is a bifunctional protein that functions as a modulator of autophagy and in gene transcription [PMID: 22470510].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER