Family

Mapk-regulated corepressor-interacting protein (IPR029428)

Short name: MCRIP

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This family consist of Mapk-regulated corepressor-interacting protein 1 (MCRIP1) and 2 (MCRIP2). MCRIP1 binds to and inhibits the transcriptional co-repressor CtBP. MCRIP1 is an ERK substrate; when phosphorylated by ERK, MCRIP1 releases CtBP to induce chromatin modifications [PMID: 25728771].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam