Domain

MDM2-binding protein, N-terminal domain (IPR029421)

Short name: MTBP_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of the MDM2-binding protein (MTBP). MDM2 is an E3 ubiquitin-protein ligase that mediates ubiquitination of p53, leading to its degradation by the proteasome [PMID: 14707283]. MTBP inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability, and this promotes MDM2-mediated ubiquitination of p53 and its subsequent degradation [PMID: 15632057]. Mouse MTBP also inhibits cancer cell migration by interacting with alpha-actinin-4 (ACTN4) [PMID: 22370640].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam