Rhamnogalacturonan lyase, domain II (IPR029413)

Short name: RG-lyase_II

Overlapping homologous superfamilies

Domain relationships



This entry represents domain II of rhamnogalacturonan lyase (RG-lyase). The full-length protein specifically recognises and cleaves alpha-1,4 glycosidic bonds between l-rhamnose and d-galacturonic acids in the backbone of rhamnogalacturonan-I, a major component of the plant cell wall polysaccharide, pectin. This domain displays an immunoglobulin-like or more specifically Fibronectin-III type fold and shows highest structural similarity to the C-terminal beta-sandwich subdomain of the pro-hormone/propeptide processing enzyme carboxypeptidase gp180 from duck. It serves to assist in producing the deep pocket, with domain III, into which the substrate fits [PMID: 15135077].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.