APCDD1 domain (IPR029405)

Short name: APCDD1

Overlapping homologous superfamilies


Domain relationships



APCDD1 is directly regulated by the beta-catenin/Tcf complex, and its elevated expression promotes proliferation of colonic epithelial cells in vitro and in vivo [PMID: 12384519]. APCDD1 has an N-terminal signal-peptide and a C-terminal transmembrane region. This domain is duplicated in most members of the family. The domain is rich in cysteines, there being up to 12 such residues, a structural motif important for interaction between Wnt ligands and their receptors. APCDD1 is expressed in a broad repertoire of cell types, indicating that it may regulate a diverse range of biological processes controlled by Wnt signalling [PMID: 20393562].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.