Domain

TERF1-interacting nuclear factor 2, N-terminal domain (IPR029400)

Short name: TINF2_N

Domain relationships

None.

Description

This entry represents the N-terminal domain of TERF1-interacting nuclear factor 2 (TINF2). It is a component of the shelterin complex (telosome), which is involved in the protection and maintenance of telomeres [PMID: 16166375, PMID: 16880378, PMID: 22201831]. TINF2 plays a role in shelterin complex assembly [PMID: 16880378]. In humans, one of its isoforms may have an additional role in tethering telomeres to the nuclear matrix [PMID: 19229133].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
CDD