Tuberoinfundibular peptide of 39 residues (IPR029396)

Short name: TIP39

Overlapping homologous superfamilies


Family relationships



This entry represents Tuberoinfundibular peptide of 39 residues (TIP39), which is a potent and selective agonist of the parathyroid hormone 2 receptor (PTH2R) [PMID: 12559132]. In human, TIP39 expression was detected by RT-PCR in the brain, trachea, fetal liver, kidney and heart. In the brain, TIP39 is expressed in only three sites, the medial and lateral parts of the subparafascicular area in the caudal thalamus, and the medial paralemnsical nucleus in the lateral pons [PMID: 19401215]. The TIP39-PTH2R system is a unique neuropeptide-receptor system that plays a role in limbic, endocrine, viscerosensory, and auditory functions [PMID: 19857544].

GO terms

Biological Process

GO:0007218 neuropeptide signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.