Family

Myeloma-overexpressed 2-like (IPR029391)

Short name: MYEOV2

Family relationships

None.

Description

This entry includes COP9 signalosome complex subunit 9, a component of the COP9 signalosome complex (CSN), which is conserved in all eukaryotes. The CSN complex is an essential regulator of the largest family of E3 ubiquitin ligases, the cullin-RING-ubiquitin ligases (CRLs). The CSN complex deactivates CRL by removing the ubiquitin-like tag NEDD8 (deneddylation) from the cullin subunit, or by binding to the deneddylated CRL, and preventing it interacting with E2 enzymes and ubiquitination substrates [PMID: 26456823].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PANTHER