Domain

AP-3 complex subunit beta, C-terminal domain (IPR029390)

Short name: AP3B_C

Domain relationships

None.

Description

This domain lies at the C terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell, as well as with more peripheral structures. Loss of functional AP-3 complex leads to defects in the function of lysosomes and lysosome-related organelles [PMID: 10024875]. The AP-3 complex seems to be involved in the trafficking of lysosomal membrane proteins from endosomes [PMID: 15051738].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam