Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain (IPR029353)

Short name: NYAP_C

Overlapping homologous superfamilies


Domain relationships



This entry represents the C-terminal domain of the neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 (NYAP1). NYAP1 belongs to the neuronal tyrosine-phosphorylated adaptor for the PI 3-kinase (NYAP) family, which consists of NYAP1, NYAP2, NAP3/Myosin16. NYAPs activate PI3K in PI3K pathway, which is a fundamental pathway for various cellular events in neurons. They also interact with components of the WAVE1 complex, which mediates actin cytoskeleton remodeling through Arp2/3 complex. It was suggested that NYAPs connect PI3K activation to WAVE1 signalling in neurons [PMID: 21946561].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.