Histone RNA hairpin-binding protein, RNA-binding domain (IPR029344)

Short name: SLBP_RNA_bind

Overlapping homologous superfamilies

Domain relationships



This entry represents the RNA-binding domain of histone RNA hairpin-binding protein, also known as SLBP [PMID: 8957003]. Proteins containing this domain include SLBP1 and SLBP2 from Xenopus laevis.

SLBP1 binds the 5' side of the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilising the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE) [PMID: 11157774]. It plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. It stabilises mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression [PMID: 18036581, PMID: 19470752, PMID: 12588979, PMID: 19155325].

SLBP2 binds to translationally inactive histone mRNA stored in immature oocytes. When oocytes mature, SLBP2 is degraded and a larger fraction of the histone mRNA is bound to SLBP1. Instead of having a role in histone pre-mRNA processing, SLBP2 may be a specific translational repressor [PMID: 9858606].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.