ITPR-interacting domain (IPR029325)

Short name: ITPR-bd

Overlapping homologous superfamilies


Domain relationships



This domain entry includes the N terminus of the actin-interacting protein sperm-specific antigen 2 (SSFA2), also known as Ki-ras-induced actin-interacting protein (KRAP) [PMID: 14673706]. In this region are found the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R, also known as ITPR). SSFA2 was first localised as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells [PMID: 14673706]. It has now been shown to be critical for the proper subcellular localisation and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialised endoplasmic reticulum membranes, so the subcellular localisation of IP3R is crucial for its proper function [PMID: 21501587].

This entry also recognises a domain in Tespa1 and in uncharacterized coiled-coil protein CCDC129. Tespa1 (thymocyte-expressed positive selection-associated protein 1) is required for the development and maturation of T-cells [PMID: 22561606]. Tespa1 shows sequence homology to SSFA2 and physically associates with IP3R in T and B lymphocytes [PMID: 23650607].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005102 signaling receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.