Domain

FANCI helical domain 1 (IPR029310)

Short name: FANCI_HD1

Domain relationships

None.

Description

FANCI and FANCD2 form a complex central to the Fanconi anemia (FA) pathway, which is essential for the repair of DNA interstrand cross-links. FANCI has four distinct alpha solenoid (alpha-alpha superhelical) segments (S1-S4). Two mostly helical segments intervene between solenoids 1 and 2 (HD1), and between solenoids 2 and 3 (HD2) [PMID: 21764741].

This is the helical domain 1 (HD1) of the Fanconi anemia complementation group I protein (FANCI).

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam