Retinoic acid early-inducible protein 1 (IPR029287)

Short name: RAE-1

Overlapping homologous superfamilies

Domain relationships


Members of this group are known as retinoic acid early inducible proteins (RAE-1) [PMID: 8882725, PMID: 10894171]. They are ligands for the activating immunoreceptor NKG2D, which is widely expressed on natural killer cells, T cells, and macrophages [PMID: 11825567]. There is a considerable diversity of NKG2D ligands. In mice, the ligands include, among others, five members of the retinoic acid early inducible gene 1 (RAE-1; alpha-epsilon) [PMID: 14523385].

RAE-1 proteins are distant major histocompatibility complex (MHC) class I homologues, comprising isolated alpha1-alpha2 platform domains [PMID: 11825567].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.