Small muscular protein Chisel (IPR029268)

Short name: Chisel

Overlapping homologous superfamilies


Family relationships



Chisel protein plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The X-linked gene Chisel (Csl/Smpx) was first found expressed selectively in human cardiac and skeletal muscle cells [PMID: 10598820]. It is expressed in embryos in sub-regions of the developing heart corresponding to the future chamber myocardium and in developing skeletal muscles [PMID: 15893749]. It is a potential target of the cardiac homeodomain transcription factor Nkx2-5 [PMID: 11381084]. It localises to the costameric cytoskeleton of muscle cells through its association with focal adhesion proteins, where it may participate in regulating the dynamics of actin through the Rac1/p38 kinase pathway [PMID: 15893749].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.