Domain

DNA-directed RNA polymerase, N-terminal (IPR029262)

Short name: RPOL_N

Domain relationships

None.

Description

This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme [PMID: 9670025]. In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site, and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex [PMID: 12242451].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART
GENE3D