PTM

Rapamycin-insensitive companion of mTOR, phosphorylation-site (IPR029259)

Short name: RICTOR_phospho

Description

The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTORC1 and mTORC2, important for nutrient- and growth-factor signalling [PMID: 20418915]. Rictor (rapamycin-insensitive companion of mTOR) is an essential component of the complex mTORC2 [PMID: 15268862]. It appears to serve as a scaffolding protein important for maintaining mTORC2 integrity. Rictor interacts with 14-3-3 in a Thr1135-dependent manner [PMID: 15268862]. Rictor can be inhibited by short-term rapamycin treatment, showing that Thr1135 is an mTORC1-regulated site [PMID: 19995915].

This short region is the phoshorylation site of Rictor.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SMART
Pfam