Protein melan-A (IPR029242)

Short name: MLANA

Overlapping homologous superfamilies


Family relationships



Melan-A, also known as melanoma antigen recognised by T-cells 1, or MART-1, is a protein that in humans is encoded by the MLANA gene. It is required for the function of the melanosomal matrix protein PMEL17/GP100 and thus plays an important role in regulating mammalian pigmentation [PMID: 15695812]. Melan-A is a member of the MAGE gene family [PMID: 11454705] and is a tumour associated antigen. Clinically, the protein may serve as an anti-cancer vaccine [PMID: 24045055].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0042470 melanosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.