Domain

Nse4/EID protein, Nse3/MAGE-binding domain (IPR029225)

Short name: Nse4_Nse3-bd

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the Nse3/MAGE (IPR002190) binding domain found in NSE4/EID family proteins [PMID: 22536443, PMID: 21364888].

Proteins in the NSE4/EID (Non-structural maintenance of chromosomes element 4/EP300-interacting inhibitor of differentiation 3) family are components of the Smc5/6 complex that is involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components [PMID: 15987788, PMID: 15752197, PMID: 20571088]. In human, it acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. It may function as a coinhibitor of other CREBBP/EP300-dependent transcription factors [PMID: 15987788].

Interestingly, there is a single NSE4 gene in most eukaryotes up to non-placental mammals while there are several NSE4/EID copies in placental mammals [PMID: 22536443]. In humans, there are two NSE4 proteins, NSE4a and NSE4b/EID3. They contain both N and C-terminal kleisin domains. Their N-terminal domain binds to the Nse3 (another SMC5-6 complex subunit) pocket [PMID: 21364888].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam