Domain

Cytoskeleton-associated protein 2, C-terminal (IPR029197)

Short name: CKAP2_C

Domain relationships

None.

Description

This entry represents the C terminus of CKAP2 (cytoskeleton-associated protein 2) and CKAP2L (cytoskeleton-associated protein 2-like). Mouse CKAP2 has been shown to possess microtubule stabilising properties [PMID: 15504249] and is involved in regulating aneuploidy, cell cycle, and cell death in a p53-dependent manner [PMID: 16061649]. In human, CKAMP2 is up-regulated in primary gastric cancers [PMID: 12942315]. It has been shown that human CKAP2 is degraded by APC/C-Cdh1 during mitotic exit and that a tight regulation of CKAP2 protein level is important for mitotic progression [PMID: 17376772].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam