Interferon lambda (IPR029177)

Short name: INF_lambda

Overlapping homologous superfamilies

Family relationships



Interferon (IFN)-lambda proteins belong to the new type III IFN group. In contrast to type I or type II IFNs, the response to type III IFN is cell-type specific. Only epithelial-like cells and some immune cells respond to IFN-lambda [PMID: 22190970]. In human,four distinct proteins called IFN-lambda1 (interleukin-29, IL-29), IFN-lambda2 (IL-28A), IFN_lambda3 (IL-28B) and IFNL4 have been identified [PMID: 20712453, PMID: 12469119, PMID: 23291588]. IFN-lambda proteins activate IFN-stimulated gene factor 3 (ISGF3), and are capable of inducing antiviral protection and MHC class I antigen expression [PMID: 22190970].

GO terms

Biological Process

GO:0051607 defense response to virus
GO:0050778 positive regulation of immune response
GO:0007259 receptor signaling pathway via JAK-STAT

Molecular Function

GO:0005125 cytokine activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.