Exocyst complex component EXOC2/Sec5 (IPR029175)

Short name: EXOC2/Sec5

Overlapping homologous superfamilies


Family relationships



This entry includes Sec5 from yeasts and EXOC2 from animals.

In S. cerevisiae, Sec5 is an essential component of the exocyst complex, which is composed of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84 [PMID: 7615633]. The exocyst complex tethers post-Golgi secretory vesicles to the plasma membrane before soluble NSF attachment protein receptor (SNARE)-mediated membrane fusion [PMID: 21997494].

In mammals, active form (GTP-bound) of Ral GTPase interacts with EXOC2 and Exo84 and regulates the assembly interface of a full octameric exocyst complex [PMID: 14525976]. Similar to yeast exocyst, the mammalian exocyst has been directly linked to post-Golgi targeting of secretory vesicles to discreet membrane sites [PMID: 14525976].

GO terms

Biological Process

GO:0006893 Golgi to plasma membrane transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000145 exocyst

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.