PEST proteolytic signal-containing nuclear protein (IPR029169)

Short name: PCNP

Overlapping homologous superfamilies


Family relationships



PCNP is a PEST-containing nuclear protein that is ubiquitinated by NIRF, a Np95/ICBP90-like RING finger protein probably involved in cell cycle regulation [PMID: 12176013]. PEST sequences, which are rich in proline (P), glutamic acid (E), serine (S) and threonine (T), are found in a number of short-lived proteins, such as transcription factors and cell cycle-associated proteins. Their function is generally controlled by proteolysis, mostly via ubiquitin-mediated degradation [PMID: 14741369]. NIRF and PCNP may constitute a novel signaling pathway with some relation to cell proliferation.

GO terms

Biological Process

GO:0016567 protein ubiquitination

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.