Family

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y (IPR029164)

Short name: PIG-Y

Overlapping homologous superfamilies

None.

Family relationships

Description

This entry represents the subunit Y of the GPI-N-acetylglucosaminyltransferase (GPI-GnT) complex found in the endoplasmic reticulum. The GPI-GnT complex catalyses the first step in the production of GPI (glycosylphosphatidylinositol)-anchors for cell surface proteins. PIG-Y may regulate activity of the complex by binding the catalytic subunit, PIG-A [PMID: 16162815]. In the absence of PIG-Y activity, the cell surface levels of GPI-anchored proteins are severely decreased [PMID: 16162815].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam